Summary

Chronic colonization of the intestinal tract is an important aspect of persistent Salmonella infection because it results in a silent propagation of bacteria in poultry stocks due to the impossibility to isolate contaminated animals. Data from our lab promote the hypothesis that Salmonellae have evolved with a unique survival strategy that minimizes host defenses (disease resistance) during the initial infection then exploits and/or induces a dramatic immunometabolic reprogramming in the cecum that alters the host defense to disease tolerance. As part of this disease tolerance, Salmonella has developed a strategy to interfere with: (a) the gut-brain circuits in poultry that promote host survival while facilitating pathogen transmission and shedding, and (b) the release of the neurochemical norepinephrine by the enteric nervous system, which inhibits the local immune defense to the pathogen colonization. Thus, evidence suggests Salmonella has developed a selection of traits that act as anti-virulence strategies in poultry, thus assuring pathogen transmission, host survival and downstream food safety issues for consumers. 

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Speakers

Dr. Michael Kogut
Microbiologist and Lead Scientist
Southern Plains Agricultural Research Center

Dr. Michael Kogut is a Research Microbiologist and Lead Scientist within the Food and Feed Safety research Unit at the Southern Plains Agricultural Research Center, College Station, TX, USA. Dr.Michael Kogut has published over 200 peer-reviewed scientific papers,11 book chapters, and has received 5 patents. Dr.Michael Kogut’s research is centered on gut health of poultry and alternatives to antibiotics to control disease and increase production. Specifically, Dr. Michael Kogut’s research has concentrated on the development of cost-effective immunological interventions to improve gut health by studying the role of the microbiota in immunity to infection; the role of dietary metabolites in promoting immune regulation and immune responses to pathogens; tissue specific regulatory responses to infection; characterizing novel molecular targets that mediate the actions of dietary compounds and botanicals in inflammation and immunity; investigating how diet modulates the gut microbiome and mucosal immune responses; and understanding the integration of central metabolic pathways and nutrient sensing with antimicrobial immunity and how it alters cellular energy homeostasis and contributes to the prevention or resolution of infectious diseases.

Andy Vance - Moderator
Director, Strategic Accounts
Farm Progress

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